With the support of her two best friends, sixteen-year-old Kathleen tries to balance her summer volunteer work at the hospital with her responsibilities caring for her mother, who has multiple sclerosis, and her attraction to a handsome boy.
After sixteen-year-old Raina learns that she is a perfect match for donating bone marrow to a leukemia patient in Virginia, she discovers that the young woman is the sister she never knew she had.
With the support of her two best friends, high school senior Holly tries to deal with the murder of her brother and her anger at God for allowing the crime to happen.